Author

M. C. Lechler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 2

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Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:protein structure· 1

Frequent Co-Authors

D. C. David· 2 shared R. Jung· 2 shared A. D. Stephens· 1 shared C. F. Kaminski· 1 shared C. H. Michel· 1 shared C. Huang· 1 shared C. Poudel· 1 shared C. Rödelsperger· 1 shared

Activity by Year

2018-2020 · peak 1/yr

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10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

D. C. David

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2 papers

Recent·Most cited

Tissue-specific safety mechanism results in opposite protein aggregation patterns during aging

R. Jung, M. C. Lechler, C. Rödelsperger, W. Röseler, R. J. Sommer, D. C. David

The paper identifies a tissue-specific safety mechanism, SAPA, that suppresses age-dependent protein aggregation in C. elegans pharyngeal muscles but not body-wall muscles.

bioRxiv · Dec 4, 2020 · PreprintCell Biology

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in C. elegans

C. Huang, S. Wagner-Valladolid, A. D. Stephens, R. Jung, C. Poudel, T. Sinnige, M. C. Lechler, N. Schlörit, R. F. Laine, C. H. Michel, M. M. Vendruscolo, C. F. Kaminski, G. S. Kaminski Schierle, D. C. David

This study shows that age-dependent protein aggregation in C. elegans forms amyloid-like structures and accelerates tissue functional decline, suggesting a role for protein aggregation in aging.

bioRxiv · Sep 14, 2018Cell Biology