Author

C. Poudel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:fluorescence / live-cell microscopy· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2

Frequent Co-Authors

C. F. Kaminski· 3 shared G. S. Kaminski Schierle· 3 shared J. C. Vaughan· 2 shared R. F. Laine· 2 shared T. Sinnige· 2 shared A. D. Stephens· 1 shared A. J. Haack· 1 shared A. Janowczyk· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

C. F. Kaminski

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Highly Multiplexed Fluorescence Microscopy with Spectrally Tunable Semiconducting Polymer Dots

Z. Guo, C. Poudel, J. Yu, M. Wong, M. C. Sarfatis, D. T. Chiu, J. C. Vaughan

This paper introduces a method for highly multiplexed fluorescence microscopy using tunable semiconducting polymer dots, enabling imaging of up to 21 targets in a single round.

bioRxiv · Dec 5, 2023 · PreprintBiochemistry

An end-to-end workflow for non-destructive 3D pathology

K. W. Bishop, L. A. E. Barner, Q. Han, E. Baraznenok, L. Lan, C. Poudel, G. Gao, R. B. Serafin, S. S. L. Chow, A. K. Glaser, A. Janowczyk, D. Brenes, H. Huang, D. Miyasato, L. D. True, , J. T. C. Liu

This paper provides an end-to-end workflow for non-destructive 3D pathology using light-sheet microscopy, focusing on fluorescent H&E analogs for preclinical and clinical studies.

bioRxiv · Aug 3, 2023 · PreprintPathology

Illuminating chromatin compaction in live cells and fixed tissues using SiR-DNA fluorescence lifetime

C. Hockings, C. Poudel, K. A. Feeney, C. L. Novo, M. S. Hamouda, I. Mela, D. Fernandez-Antoran, P. P. Vallejo Ramirez, P. Rugg-Gunn, K. Chalut, C. F. Kaminski, G. S. Kaminski Schierle

This paper develops a method to measure chromatin compaction in live and fixed cells using SiR-DNA fluorescence lifetime, revealing compaction in differentiating cells and decompaction during stem cell transitions.

bioRxiv · May 2, 2020 · PreprintCell Biology

Pyruvate kinase controls signal strength in the insulin secretory pathway

S. L. Lewandowski, R. L. Cardone, H. R. Foster, T. Ho, E. Potapenko, C. Poudel, H. R. VanDeusen, T. C. Alves, X. Zhao, M. E. Capozzi, I. Jahan, C. S. Nunemaker, J. E. Campbell, C. J. Thomas, R. G. Kibbey, M. J. Merrins

This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.

bioRxiv · Jan 15, 2020Cell Biology

Fast fluorescence lifetime imaging reveals the aggregation processes of α-synuclein and polyglutamine in aging Caenorhabditis elegans

R. F. Laine, T. Sinnige, K. Y. Ma, A. J. Haack, C. Poudel, P. Gaida, N. Curry, M. Perni, E. A. A. Nollen, C. M. Dobson, M. Vendruscolo, G. S. Kaminski Schierle, C. F. Kaminski

This study uses fast TG-FLIM to analyze α-synuclein and polyglutamine aggregation in aging C. elegans, revealing differences in their aggregation kinetics and amyloid-like features.

bioRxiv · Nov 16, 2018Biophysics

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in C. elegans

C. Huang, S. Wagner-Valladolid, A. D. Stephens, R. Jung, C. Poudel, T. Sinnige, M. C. Lechler, N. Schlörit, R. F. Laine, C. H. Michel, M. M. Vendruscolo, C. F. Kaminski, G. S. Kaminski Schierle, D. C. David

This study shows that age-dependent protein aggregation in C. elegans forms amyloid-like structures and accelerates tissue functional decline, suggesting a role for protein aggregation in aging.

bioRxiv · Sep 14, 2018Cell Biology