Author

M. C. Seabra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:electronic health records· 1

Frequent Co-Authors

C. Escrevente· 3 shared D. C. Barral· 3 shared M. J. Hall· 3 shared M. V. Neto· 3 shared C. E. Futter· 2 shared J. Charneca· 2 shared A. C. Fradinho· 1 shared A. Oliva· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

C. Escrevente

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Author profile →

5 papers

Recent·Most cited

Photoprotective melanin is maintained within keratinocytes in a storage lysosome

M. V. Neto, M. J. Hall, J. Charneca, C. Escrevente, M. C. Seabra, D. C. Barral

The paper shows melanin-containing phagosomes in keratinocytes mature into storage lysosomes called melanokerasomes, which retain melanin for long-term photoprotection.

bioRxiv · Feb 5, 2024Cell Biology

Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer.

M. J. Hall, S. Lopes-Ventura, M. V. Neto, J. Charneca, P. Zoio, M. C. Seabra, A. Oliva, D. C. Barral

The paper demonstrates that 3D reconstructed human pigmented skin models exhibit epidermal pigmentation through melanocore transfer, comparable to human skin.

bioRxiv · Mar 3, 2022Cell Biology

FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION

C. Escrevente, A. S. Falcao, M. J. Hall, M. Lopes-da-Silva, P. Antas, M. M. Mesquita, I. S. Ferreira, M. H. Cardoso, A. C. Fradinho, C. E. Futter, S. Tenreiro, M. C. Seabra

This study shows that lysosomal dysfunction leads to incomplete degradation of photoreceptor outer segments and accumulation of autofluorescent granules in RPE cells.

Investigative Opthalmology & Visual Science · Jul 27, 2021Peer-reviewedCell Biology

Melanocore uptake by keratinocytes occurs through phagocytosis and involves Protease-activated receptor-2 activation

H. Moreiras, M. V. Neto, L. B. Lopes, C. Escrevente, J. S. Ramalho, M. C. Seabra, D. C. Barral

The paper investigates how melanocores and melanosomes are internalized by keratinocytes, finding that melanocores are taken up via phagocytosis involving PAR-2 activation, while melanosomes use macropinocytosis.

bioRxiv · Apr 13, 2021 · PreprintCell Biology

Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

I. P. Meschede, M. C. Seabra, C. E. Futter, M. Votruba, M. E. Cheetham, T. Burgoyne

The paper examines the specialized arrangement of mitochondria in photoreceptor inner segments and shows that Opa1 regulates their contact with the plasma membrane.

bioRxiv · May 21, 2019Cell Biology