T. Burgoyne

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations

This study identifies CFAP418's role in lipid binding and membrane processes, showing that its disruption causes lipid imbalance and mitochondrial defects in retinal degenerations.

Fission of megamitochondria into multiple smaller well-defined mitochondria in the ageing zebrafish retina

The paper examines mitochondrial changes in zebrafish retina over time, finding that mitochondria become smaller and more defined with age, likely due to oxidative stress and light exposure.

Ultrastructural insight into SARS-CoV-2 attachment, entry and budding in human airway epithelium

This study uses electron microscopy to examine SARS-CoV-2 infection in human airway epithelium, showing viral entry through the plasma membrane and budding from intracellular compartments.

Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

This study shows that SARS-CoV-2 variant B.1.1.7 does not replicate better in airway cells or escape antibodies, suggesting its increased transmissibility is due to other factors.

Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

The paper examines the specialized arrangement of mitochondria in photoreceptor inner segments and shows that Opa1 regulates their contact with the plasma membrane.

Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

This study shows that agonist binding affinity affects GLP-1R palmitoylation, nanodomain clustering, and signaling in pancreatic beta cells, influencing insulin secretion.

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.