M. C. Wahl

Sm-like protein Rof inhibits transcription termination factor Rho by binding site obstruction and conformational insulation

This study identifies Rof as an inhibitor of the transcription termination factor Rho, showing it blocks Rho's activity through structural obstruction and conformational changes.

Transcription termination factor {rho} polymerizes under stress

This study shows that Escherichia coli {rho} forms higher-order oligomers under stress, linking transcription termination to cellular physiology.

Rapid high-resolution structure analysis of small, biotechnologically relevant enzymes by cryo-electron microscopy

This study demonstrates that cryo-EM can achieve high-resolution structures of small plant enzymes, enabling faster development of biocatalysts for terpenes and terpenoids.

Long-range allosteric effects - How adenine nucleotides shape the conformational landscape of the Ski2-like RNA helicase, Brr2

This study investigates how adenine nucleotides influence the conformational dynamics of Brr2, revealing long-range allosteric effects between its cassettes.

The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations

The paper examines how somatic cancer mutations in ASCC2 and ASCC3 affect their interaction, reducing affinity and potentially impacting DNA repair.

Positive and negative intra-molecular modulation in a dual-cassette RNA helicase

This study shows that the inactive C-terminal cassette of Brr2 can both positively and negatively modulate the active N-terminal cassette's RNA-related activities through structural changes.

Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase

The paper presents crystal structures of Brr2 to elucidate mechanisms inhibiting intrinsic ATPase activity and how RNA binding stimulates it.