Author

M. Calderwood

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Spirohn· 2 shared M. Vidal· 2 shared A. Bateman· 1 shared A. Carpenter· 1 shared A. Desbuleux· 1 shared A. G. Cote· 1 shared A. O. Speak· 1 shared A. Schejtman· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

K. Spirohn

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Author profile →

3 papers

Recent·Most cited

Pervasive mislocalization of pathogenic coding variants underlying human disorders

J. Lacoste, M. Haghighi, S. Haider, Z.-Y. Lin, D. Segal, C. Reno, W. W. Qian, X. Xiong, H. Shafqat-Abbasi, P. Ryder, R. Senft, B. Cimini, F. Roth, M. Calderwood, D. Hill, , M. Taipale

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

bioRxiv · Sep 5, 2023Cell Biology

Next-generation large-scale binary protein interaction network for Drosophila

H.-W. Tang, K. Spirohn, Y. Hu, T. Hao, I. A. Kovacs, Y. Gao, R. Binari, D. Yang-Zhou, K. H. Wan, J. S. Bader, D. Balcha, W. Bian, B. W. Booth, A. G. Cote, S. De Rouck, , S. Mohr

The paper generates a high-confidence binary protein interaction network for Drosophila using yeast two-hybrid screens and integrates it with existing data to create a comprehensive reference network.

Nature Communications · Apr 15, 2023Peer-reviewedCell Biology

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology