Author

A. O. Speak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Brandt· 2 shared A. Bateman· 1 shared A. Gillis· 1 shared A. J. Bancroft· 1 shared A. J. Reid· 1 shared A. Schejtman· 1 shared A. Swiatkowska· 1 shared C. Cormie· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

C. Brandt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology

Defining the early stages of intestinal colonisation by whipworms

M. A. Duque Correa, D. Goulding, F. Rodgers, C. Cormie, K. A. Rawlinson, A. Gillis, A. J. Bancroft, H. M. Bennett, M. Lotkowska, A. J. Reid, A. O. Speak, P. Scott, N. Redshaw, C. McCarthy, C. Brandt, , M. Berriman

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

bioRxiv · Aug 21, 2020Immunology

A genome-wide screen in mice to identify cell-extrinsic regulators of pulmonary metastatic colonisation

L. van der Weyden, A. Swiatkowska, V. Iyer, A. O. Speak, D. J. Adams

The paper identifies 34 genes that regulate pulmonary metastatic colonisation in mice through a genome-wide screen using mutant mice and metastatic melanoma cells.

bioRxiv · Feb 10, 2020Cancer Biology