H. Lim

The Chemokine Receptor CCR8 is Not a High-affinity Receptor for the Human Chemokine CCL18

The paper investigates whether CCR8 is a high-affinity receptor for CCL18 and finds that CCR8 does not respond to CCL18 in multiple assays.

Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.

This study identifies epithelial NMDA receptors in the kidney that mediate vasodilation via connecting-tubule-glomerular feedback by enhancing ENaC activity.

An eco-physiological model of forest photosynthesis and transpiration under combined nitrogen and water limitation

The paper develops an eco-physiological model to predict combined effects of water and nitrogen limitations on forest growth using optimality principles and validates it with field measurements.

A developmentally-inspired hypoxia condition promotes kidney organoid differentiation from human pluripotent stem cells

This study uses hypoxia to improve kidney organoid differentiation from hPSCs, resulting in more mature structures with collecting ducts and potential for disease modeling.

Next-generation large-scale binary protein interaction network for Drosophila

The paper generates a high-confidence binary protein interaction network for Drosophila using yeast two-hybrid screens and integrates it with existing data to create a comprehensive reference network.

Mass cytometry identifies dysregulation of circulating and cutaneous immune cells in patients with hidradenitis suppurativa

This study identifies immune cell dysregulation in hidradenitis suppurativa using mass cytometry and RNA-seq, finding increased CD38 expression in monocytes and suggesting CD38 as a therapeutic target.

PtrR (YneJ) is a novel E. coli transcription factor regulating the putrescine stress response and glutamate utilization

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

Single-cell analysis of a mutant library generated using CRISPR-guided deaminase

The paper develops a CRISPR-based platform combining deaminase and scRNA-seq to introduce and assess substitution mutations, enabling high-throughput analysis of mutation-associated transcriptional effects.

Multiplex generation, tracking, and functional screening of substitution mutants using a CRISPR/retron system

This paper develops a CRISPR/retron system for high-throughput generation and tracking of substitution mutations in E. coli, enabling genome-scale screening of chemical responses and fitness changes.

Ploidy tug-of-war: evolutionary and genetic environments influence the rate of ploidy drive in a human fungal pathogen

This study investigates how environmental and genetic factors influence ploidy drive in Candida albicans by evolving strains under different nutrient limitations.