M. Caron

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

New RoxS sRNA targets identified in B. subtilis by pulsed SILAC

This study identifies new RoxS sRNA targets in B. subtilis using pulsed SILAC, confirming known targets and expanding the list of TCA cycle enzymes regulated primarily at the translational level.

Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi:β-arrestin complexes

The paper shows that biased agonists of CXCR3 differentially drive the formation of Gi:β-arrestin complexes, independent of G protein signaling or β-arrestin recruitment.

Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity

This study analyzes single-cell transcriptomes of childhood leukemia patients to show that developmental state and ribosomal protein expression contribute to intra-individual heterogeneity.

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.