N. Krogan

Spatial control of sensory adaptation modulates mechanosensing in Pseudomonas aeruginosa

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.

The Chlamydia trachomatis Inc Tri1 interacts with TRAF7 to displace native TRAF7 interacting partners

This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

Two accessory proteins govern MmpL3 mycolic acid transport in mycobacteria

This study identifies two new proteins involved in the MmpL3-mediated mycolic acid transport in mycobacteria, revealing their roles in transport and stress response.

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.

Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity

This study identifies a mechanism by which Unc93b1 recruits Syntenin-1 to specifically inhibit TLR7 signaling and prevent autoimmunity.

Evolutionary proteomics uncovers ciliary signaling components

The paper uses proteomic analysis of cilia from diverse organisms to identify conserved ciliary proteins and their ancient signaling connections, revealing a novel protein involved in vertebrate development and human disease.