Cancer BiologybioRxivPreprint
Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis
Vasileios Chortis, Kleiton Silva Borges, Cong-Hui Yao…·David T. Breault
This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.