ANGELA E. R. TAYLOR

Physiological and behavioural characterisation of a novel steroid sulfatase-deficient mouse

This study creates a STS-deficient mouse model and finds sex-specific behavioral and physiological differences linked to STS deficiency.

Inhibition of the androgen-activating enzyme AKR1C3 selectively decreases systemic and intra-adipose 11-oxygenated androgens in women

Inhibition of AKR1C3 reduces 11-oxygenated androgens but not classic androgens in women.

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies

The paper develops a mouse model of aldosterone-producing adenoma to test thermal ablation therapies, showing reduced aldosterone production after treatment.

Alternative pathway androgen biosynthesis and human fetal female virilization

The paper demonstrates an alternative androgen biosynthesis pathway in human fetal females with congenital adrenal hyperplasia due to P450 oxidoreductase deficiency, leading to virilization despite low circulating androgens.