Author

Vasileios Chortis

Boston Children's HospitalORCID 0000-0002-4906-8239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Betül Haykir· 2 shared David T. BreaultiD· 2 shared Diana L. CarloneiD· 2 shared Felix BeuschleiniD· 2 shared Kleiton Silva BorgesiD· 2 shared Mesut BerberiD· 2 shared Alcides Euzebio Tavares XavieriD· 1 shared Alessandro PreteiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Betül Haykir

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Rho-ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal via adherens junctions

Mesut Berber, Betül Haykir, Nick A. Guagliardo, Vasileios Chortis, Kleiton Silva Borges, Paula Q. Barrett, Felix Beuschlein, Diana L. Carlone, David T. Breault

This study shows that β-Catenin-driven hyperplasia in the adrenal cortex is mediated through Rho-ROCK signaling and Cat-dependent stabilization of adherens junctions.

Journal of Clinical Investigation · Jan 27, 2026Peer-reviewedCell Biology

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

Vasileios Chortis, Kleiton Silva Borges, Cong-Hui Yao, Claudio Henrique T. Ribeiro, Luís Fernando Peinado Nagano, Mesut Berber, Alessandro Prete, Lukáš Najdekr, Michail E. Klontzas, Andris Jankevics, Pedro Henrique Vendramini, Jean Lucas Kremer, Liam Kelley, Sathuwarman Raveenthiraraj, Alcides Euzebio Tavares Xavier, , David T. Breault

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

bioRxiv · Sep 28, 2025 · PreprintCancer Biology