Author

M. Cyrklaff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Organism:plant (other)· 2

Frequent Co-Authors

C. Funaya· 3 shared F. Frischknecht· 3 shared J. Guizetti· 3 shared C. P. Sanchez· 2 shared C. S. Simon· 2 shared D. Klaschka· 2 shared J. Kim· 2 shared M. Ganter· 2 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

C. Funaya

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Microtubule inner proteins of Plasmodium are essential for transmission of malaria parasites

F. Hentzschel, A. M. Binder, L. P. Dorner, L. Herzel, F. Nuglish, M. Sema, M. C. Aguirre-Botero, M. Cyrklaff, C. Funaya, F. Frischknecht

This study investigates the role of four MIPs in Plasmodium transmission, finding that two are essential for gamete formation and mosquito transmission.

bioRxiv · Oct 19, 2023Microbiology

Reversible brain edema in experimental cerebral malaria is associated with transcellular blood-brain barrier disruption and delayed microhemorrhages

A. Hoffmann, J. Jin, M. Aida, C. H. Wai, S. Mohanty, P. K. Sahu, R. Pattnaik, L. Pirpamer, M. Fischer, S. Heiland, M. Lanzer, F. Frischknecht, A.-K. Mueller, J. Pfeil, M. Majhi, , M. Bendszus

This study identifies transcellular blood-brain barrier disruption as a mechanism for reversible brain swelling in experimental cerebral malaria, with implications for therapeutic strategies.

bioRxiv · Nov 26, 2021 · PreprintNeuroscience

KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in P. falciparum-infected erythrocytes

C. P. Sanchez, P. Patra, S.-Y. Chang, C. Karathanasis, L. Hanebutte, N. Kilian, M. Cyrklaff, M. Heilemann, U. S. Schwarz, M. Kudryashev, M. Lanzer

This study uses super-resolution microscopy to show KAHRP relocalizes to remnant actin junctions and associates with spiral scaffolds in P. falciparum-infected erythrocytes.

bioRxiv · May 12, 2021Microbiology

Asynchronous nuclear cycles in multinucleated Plasmodium falciparum enable rapid proliferation

S. Klaus, P. Binder, J. Kim, M. Machado, C. Funaya, V. Schaaf, D. Klaschka, A. Kudulyte, M. Cyrklaff, V. Laketa, T. Hoefer, J. Guizetti, N. Becker, F. Frischknecht, U. S. Schwarz, M. Ganter

The paper shows that Plasmodium falciparum nuclei replicate DNA asynchronously, leading to heterogeneous progeny numbers and slower replication during overlapping events.

bioRxiv · Apr 15, 2021Microbiology

An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum

C. S. Simon, C. Funaya, J. Bauer, Y. Voss, M. Machado, A. Penning, D. Klaschka, M. Cyrklaff, J. Kim, M. Ganter, J. Guizetti

This study identifies an extended intranuclear compartment in Plasmodium falciparum that nucleates microtubules during schizogony, revealing a novel centrosome structure.

bioRxiv · Mar 12, 2021Cell Biology

Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

M. Diehl, S. Weber, M. Cyrklaff, C. P. Sanchez, C. A. Beretta, L. Roling, C. S. Simon, J. Guizetti, M. P. Mayer, J. M. Przyborski

This study shows that the malaria parasite protein PFA66, a J-domain protein, works with host-derived HSP70 to facilitate knob biogenesis and cytoadherence in infected erythrocytes.

bioRxiv · Mar 11, 2021Cell Biology