S. Weber

Graphical pangenomics-enabled characterisation of structural variant impact on gene expression in Brassica napus

This study uses pangenome graphs to analyze structural variants in Brassica napus, showing they impact gene expression and eQTL analysis better than single references.

Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc

This paper characterizes two anti-Arc nanobodies that bind to the ligand-binding pocket of human Arc-NL, revealing their structural and functional properties as competitive inhibitors.

Facilitating taxonomy and phylogenetics: An informative and cost-effective protocol integrating long amplicon PCRs and third-generation sequencing

This paper introduces a cost-effective PCR-based protocol for generating long amplicons of mitochondrial and nuclear genes in spiders, enabling accurate phylogenetic inference with low infrastructure requirements.

Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs

This study uses 3D spatiotemporal analysis to show that SARS-CoV-2 infection in hamsters leads to monocyte-derived macrophage infiltration, vascular damage, and virus clearance, followed by tissue remodeling and fibrosis.

Environmental DNA from archived leaves reveals widespread temporal turnover and biotic homogenization in forest arthropod communities

The paper uses environmental DNA from archived leaves to show temporal turnover and biotic homogenization in forest arthropod communities, not widespread declines in diversity.

Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic

This study determines the minimum infective dose of SARS-CoV-2 for Golden Syrian hamsters and highlights their high susceptibility, suggesting a potential zoonotic risk.

Malaria transmission relies on concavin-mediated maintenance of Plasmodium sporozoite cell shape

This study identifies concavin as a protein essential for maintaining Plasmodium sporozoite shape during mosquito transmission and skin migration, with its absence leading to shape defects and reduced transmission efficiency.

Stereo-specific Lasofoxifene Derivatives Reveal the Interplay between Estrogen Receptor Alpha Stability and Antagonistic Activity in ESR1 Mutant Breast Cancer Cells

The paper synthesizes lasofoxifene derivatives to study how ER cellular lifetime and antagonistic activity relate in ESR1 mutant breast cancer cells, finding that reducing ER lifetime does not always enhance transcriptional antagonism.

Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

This study shows that the malaria parasite protein PFA66, a J-domain protein, works with host-derived HSP70 to facilitate knob biogenesis and cytoadherence in infected erythrocytes.

Molecular diet analysis in zebra and quagga mussels (Dreissena spp.) and an assessment of the utility of aquatic filter feeders as biological eDNA filters

The paper develops primers to analyze mussel diets and assess their role in filtering eDNA, showing they reflect plankton diversity and can detect pathogens.

Glycosaminoglycans are specific endosomal receptors for Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor

This paper identifies heparan sulfate proteoglycans as essential host factors for Yersinia pseudotuberculosis CNFY toxin intoxication, showing that conformational changes and heparanase activity are critical for toxin uptake and function.

METABOLIC DIVERSITY IN HUMAN NON-SMALL CELL LUNG CANCER CELLS

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.

Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation

This study identifies hypoxia-induced epigenetic silencing of PLK2 and its role in promoting atrial fibrosis via OPN secretion in AF.