Author

C. J. Bierle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. Biolatti· 2 shared R. S. Harris· 2 shared V. Dell'Oste· 2 shared A. A. Zaidi· 1 shared A. Auerbach· 1 shared A. Cheng· 1 shared A. Crane· 1 shared A. W. Grande· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

M. Biolatti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Classical guinea pig coat phenotypes are associated with variants in FGF5 and CELSR1

M. Halley, C. J. Bierle, P. Hsieh, A. A. Zaidi, F. W. Albert, Maureen Cetera

This study identifies genetic variants in FGF5 and CELSR1 associated with long and rough coat phenotypes in guinea pigs, revealing distinct molecular mechanisms.

bioRxiv · Nov 3, 2026 · PreprintGenetics

Human Trophoblast Stem Cells Restrict Human Cytomegalovirus Replication

T. B. Rollman, Z. W. Berkebile, H. Okae, V. J. Bardwell, M. D. Gearhart, C. J. Bierle

This study shows that human trophoblast stem cells restrict HCMV replication but alter gene expression related to differentiation and cell fate, potentially impairing placental function.

bioRxiv · Dec 13, 2023Microbiology

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism

R. S. Harris, E. Fanunza, A. Cheng, A. Auerbach, B. Stefanovska, S. N. Moraes, J. Lokensgard, M. Biolatti, V. Dell'Oste, C. J. Bierle, W. A. Bresnahan

This paper shows that human cytomegalovirus (HCMV) relocalizes APOBEC3B from the nucleus to the cytoplasm through an RNR-independent mechanism, unlike related herpesviruses.

bioRxiv · Jan 30, 2023Microbiology

Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through upregulation of memory T-cells

A. Crane, M. R. Chrostek, V. D. Krishna, M. Shiao, N. G. Toman, C. M. Pearce, S. K. Tran, C. J. Sipe, W. Guo, J. P. Voth, S. Vaid, H. Xie, W.-C. Lu, W. Swanson, A. W. Grande, , W. C. Low

This study shows that Zika virus-based immunotherapy improves long-term survival in mice with brain tumors by boosting memory T-cell levels.

PLOS ONE · Oct 1, 2020Peer-reviewedCancer Biology

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

A. Z. Cheng, S. Nobrega de Moraes, C. Attarian, J. Yockteng-Melgar, M. C. Jarvis, M. Biolatti, G. Galitska, V. Dell'Oste, L. Frappier, C. J. Bierle, S. A. Rice, R. S. Harris

This study shows that herpesviruses use viral ribonucleotide reductase subunits to relocalize APOBEC3B and APOBEC3A, suggesting a conserved mechanism to evade innate immunity.

bioRxiv · Sep 13, 2019Microbiology