M. D. Robinson

The structure of yeast Npl3 bound to RNA reveals a cooperative sequence-specific recognition and an RNA chaperone role in splicing

This study determines the RNA-binding specificity of yeast Npl3's RRMs using NMR structures and shows its role in melting U2 snRNA for splicing.

Mass Cytometric and Transcriptomic Profiling of Epithelial-Mesenchymal Transitions in Human Mammary Cell Lines

The paper profiles EMT transition phenotypes in human mammary cell lines using mass cytometry and transcriptomics to understand phenotypic diversity across time and cell lines.

Loss of C3aR induces immune infiltration and inflammatory microbiota in a novel spontaneous model of colon cancer

This study shows that loss of C3aR in a mouse model of colon cancer leads to immune infiltration and inflammatory microbiota changes.

A cis-regulatory element promoting increased transcription at low temperature in cultured ectothermic Drosophila cells

The paper identifies a cis-regulatory element that promotes transcriptional upregulation at low temperatures in Drosophila cells.

TNFR2 induced priming of NLRP3-inflammasome via RIPK1 leads to pyroptosis in XIAP deficient cells

The paper shows TNFR2 activation in XIAP-deficient cells leads to NLRP3 inflammasome priming and pyroptosis via RIPK1 and ROS, with implications for reducing IL-18 release in XLP-2 patients.

The proto CpG island methylator phenotype of sessile serrated adenoma/polyps

This paper identifies distinct DNA methylation patterns in sessile serrated adenomas/polyps (SSA/Ps) compared to conventional adenomas, introducing the term 'proto-CIMP' and highlighting their potential as biomarkers.