B. Bodenmiller

SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

This study shows SMAC mimetics overcome apoptotic resistance in ovarian cancer by targeting the MSLN-TNF alpha axis, enhancing cell death and synergizing with chemotherapy.

Standardization of suspension and imaging mass cytometry readouts for clinical decision making

This study standardizes suspension and imaging mass cytometry measurements to improve clinical reproducibility and provide oncologists with tumor biology insights.

A Cancer-Associated Fibroblast Classification Framework for Single-Cell Data

The paper classifies cancer-associated fibroblasts (CAFs) using single-cell RNA sequencing data from breast cancer patients and validates the classification in other cancer types.

Cross-species analysis identifies conserved transcriptional mechanisms of neutrophil maturation

The paper identifies conserved transcriptional mechanisms of neutrophil maturation across zebrafish, mouse, and human by generating high-resolution transcriptional profiles and cross-species comparisons.

Acquired resistance to anti-PD1 therapy in patients with NSCLC reveals changes in T cell phenotypes and MET amplification

This study identifies two patterns of acquired resistance to anti-PD1 therapy in NSCLC patients, including reduced T cell infiltration and MET amplification.

Multiplexed Imaging Mass Cytometry of Chemokine Milieus in Metastatic Melanoma Characterizes Features of Response to Immunotherapy

The paper characterizes chemokine landscapes in metastatic melanoma using multiplexed imaging mass cytometry, linking chemokine expression to immune infiltration and response to immunotherapy.

Exploration and analysis of molecularly annotated, 3D models of breast cancer at single-cell resolution using virtual reality

The paper introduces Theia, a virtual reality platform for exploring 3D molecularly annotated cancer datasets, and provides breast cancer datasets for analysis.

The Imaging and Molecular Annotation of Xenografts and Tumours (IMAXT) High Throughput Data and Analysis Infrastructure

The paper presents an infrastructure for high-throughput data and analysis of tumour and xenograft samples using multimodal imaging and molecular annotation.

Mass Cytometric and Transcriptomic Profiling of Epithelial-Mesenchymal Transitions in Human Mammary Cell Lines

The paper profiles EMT transition phenotypes in human mammary cell lines using mass cytometry and transcriptomics to understand phenotypic diversity across time and cell lines.

Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate Cancer

This study uses single-cell proteomics to identify cellular heterogeneity in localized prostate cancer and discovers rare subpopulations associated with advanced disease.

A distinct innate immune signature marks progression from mild to severe COVID-19

The paper identifies an innate immune signature associated with progression from mild to severe COVID-19 using mass cytometry and proteomics.

Lymphopenia-induced T cell proliferation is a hallmark of severe COVID-19

This study identifies T cell apoptosis and migration as mechanisms of peripheral T cell lymphopenia in severe COVID-19 and links lymphopenia to subsequent T cell proliferation.

Highly multiplexed molecular and cellular mapping of breast cancer tissue in three dimensions using mass tomography.

This study introduces mass tomography to enable 3D analysis of breast cancer tissue using imaging mass cytometry, revealing spatial heterogeneity and micro-invasion dynamics.