Author

W. W.-L. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. M. Spilgies· 2 shared L. Vasilikos· 2 shared B. G. Hale· 1 shared D. Eletto· 1 shared E. Moritz· 1 shared H. Wajant· 1 shared I. Busnadiego· 1 shared J. Börold· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

L. M. Spilgies

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Author profile →

3 papers

Recent·Most cited

Genome-Wide CRISPR Screening Identifies BRD9 as a Druggable Component of Interferon-Stimulated Gene Expression and Antiviral Activity

J. Börold, D. Eletto, I. Busnadiego, N. K. Mair, E. Moritz, S. Schiefer, N. Schmidt, P. P. Petric, W. W.-L. Wong, M. Schwemmle, B. G. Hale

This study identifies BRD9 as a critical component of IFN signaling and antiviral activity through CRISPR screening, showing its druggability for targeting constitutive ISG expression.

bioRxiv · Feb 4, 2021Immunology

Tumor cell-derived lymphotoxin alpha triggers metastatic extravasation through TNFRs/cIAP1

L. Vasilikos, K. Haenggi, L. M. Spilgies, W. W.-L. Wong

The paper shows Smac mimetics reduce metastasis by targeting cIAP1, altering endothelial barriers, and disrupting LTA/TNFR-mediated tumor cell extravasation.

bioRxiv · Sep 14, 2019Cancer Biology

TNFR2 induced priming of NLRP3-inflammasome via RIPK1 leads to pyroptosis in XIAP deficient cells

J. Knop, L. M. Spilgies, S. Rufli, R. Reinhardt, L. Vasilikos, M. Yabal, P. J. Jost, H. Wajant, M. D. Robinson, T. Kaufmann, W. W.-L. Wong

The paper shows TNFR2 activation in XIAP-deficient cells leads to NLRP3 inflammasome priming and pyroptosis via RIPK1 and ROS, with implications for reducing IL-18 release in XLP-2 patients.

bioRxiv · Feb 15, 2019Immunology