Author

M. D. Walkinshaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. Georgiou· 2 shared J. Michel· 2 shared A. A. Gupta· 1 shared A. De Simone· 1 shared A. J. Baldwin· 1 shared A. Mey· 1 shared A. N. Hulme· 1 shared C. Ioannidis· 1 shared

Activity by Year

2017-2019 · peak 1/yr

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10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

C. Georgiou

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2 papers

Recent·Most cited

BiophysicsbioRxivSep 17, 2019

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of Cyclophilin A

J. Juarez-Jimenez, A. A. Gupta, G. Karunanithy…·J. Michel

The paper uses accelerated MD and MSM to study millisecond timescale conformational dynamics of CypA, identifying key states and validating predictions with NMR.

DOI 10.1039/c9sc04696h

protein structuredeep learning

𝕏 PostBluesky

BiophysicsbioRxivJun 15, 2017

Pushing The Limits Of Detection Of Weak Binding Using Fragment Based Drug Discovery: Identification Of New Cyclophilin Binders

C. Georgiou, I. W. McNae, M. A. Wear…·M. D. Walkinshaw

This paper identifies novel cyclophilin binders using fragment-based drug discovery and combines X-ray diffraction, SPR, and MD simulations to better characterize weak binding events.

DOI 10.1016/j.jmb.2017.06.016

protein structureexperimental assay

𝕏 PostBluesky