Author

A. Mey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

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Research Focus:protein folding & dynamics· 4 Approach:deep learning· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Michel· 2 shared A. A. Gupta· 1 shared A. De Simone· 1 shared A. J. Baldwin· 1 shared A. N. Hulme· 1 shared A. Pandini· 1 shared A. Ramanathan· 1 shared B. Islam· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

J. Michel

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4 papers

Recent·Most cited

Structural dynamics of the β-coronavirus Mpro protease ligand binding sites

E. Cho, M. Rosa, R. Anjum, S. Mehmood, M. Soban, M. Mujtaba, K. Bux, S. C. Dantu, A. Pandini, J. Yin, H. Ma, A. Ramanathan, B. Islam, A. Mey, D. BHOWMIK, S. Haider

The paper compares ligand-binding sites of Mpro proteases from SARS-CoV2, SARS-CoV, and MERS-CoV using deep learning and Markov state models to assess structural dynamics and conservation.

bioRxiv · Mar 31, 2021 · PreprintBiophysics

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of Cyclophilin A

J. Juarez-Jimenez, A. A. Gupta, G. Karunanithy, A. Mey, C. Georgiou, C. Ioannidis, A. De Simone, P. N. Barlow, A. N. Hulme, M. D. Walkinshaw, A. J. Baldwin, J. Michel

The paper uses accelerated MD and MSM to study millisecond timescale conformational dynamics of CypA, identifying key states and validating predictions with NMR.

bioRxiv · Sep 17, 2019Biophysics

Geometric constraints in protein folding

N. Molkenthin, S. Muehle, A. Mey, M. Timme

This paper introduces a simple geometric model of protein folding that reproduces key ensemble properties of real protein structures, suggesting geometric constraints alone can explain generic features of tertiary structures.

bioRxiv · Dec 23, 2018 · PreprintBiophysics

Allosteric effects in catalytic impaired variants of the enzyme cyclophilin A may be explained by changes in nano-microsecond time scale motions

P. Wapeesittipan, A. Mey, m. walkinshaw, J. Michel

This study uses MD simulations to show that catalytic impairment in CypA mutants is linked to faster nano-microsecond motions of Phe113, challenging the role of millisecond-scale conformational changes in allosteric effects.

bioRxiv · Oct 10, 2018 · PreprintBiophysics