A. J. Baldwin

Seedless: On-the-fly pulse calculation for NMR experiments

Seedless calculates NMR pulses on-the-fly to improve signal-to-noise by compensating for RF inhomogeneity and chemical shift effects.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD

This study identifies molecular determinants of dynamic protein-protein interactions in DsbD using NMR, molecular dynamics, and AlphaFold modeling, revealing redox-state-dependent binding and a putative thioredoxin binding site.

Repulsive electrostatic interactions modulate dense and dilute phase properties of biomolecular condensates

The paper shows that repulsive electrostatic interactions influence the properties of biomolecular condensates, with net charge affecting their formation and behavior in both cellular and in vitro settings.

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of Cyclophilin A

The paper uses accelerated MD and MSM to study millisecond timescale conformational dynamics of CypA, identifying key states and validating predictions with NMR.

Local unfolding of the HSP27 monomer regulates chaperone activity

This study shows that redox-induced monomerization of HSP27 enhances its chaperone activity but also increases aggregation risk, with mutations in an unstructured region linked to neuropathies.