Clonal expansion of personalized anti-tumor T cells from circulation using tumor organoid-immune co-cultures
Q. Meng, S. Xie, K. Gray, W. Li, L. Huang, D. Akshinthala, M. Dezfulian, E. Ferrer, C. Conahan, S. Del Pino, J. Grossman, S. Elledge, M. Hidalgo, S. K. Muthuswamy
This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.
bioRxiv · Nov 6, 2020 · PreprintCancer Biology