Author

S. Elledge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. A. Wells· 2 shared L. L. Kirkemo· 2 shared A.-L. Barabasi· 1 shared A.-M. Liebhoff· 1 shared B. Langmead· 1 shared B. S. Zha· 1 shared C. Conahan· 1 shared C. J. Donahue· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

J. A. Wells

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn

A.-M. Liebhoff, T. Venkataraman, W. R. Morgenlander, M. Na, T. Kula, K. Waugh, C. Morrison, M. Rewers, R. Longman, J. Round, S. Elledge, I. Ruczinski, B. Langmead, H. B. Larman

The paper develops Dolphyn, a machine learning method to improve PhIP-Seq by prioritizing epitopes, increasing antibody-bound peptides from 10% to 31% and reducing synthesized peptides by 78%.

bioRxiv · Jul 30, 2023Bioengineering

Cell-surface tethered promiscuous biotinylators enable small-scale surface proteomics of human exosomes

L. L. Kirkemo, S. Elledge, J. Yang, J. R. Byrnes, J. E. Glasgow, R. Blelloch, J. A. Wells

This paper introduces two methods for rapid, small-scale cell surface biotinylation using tethered enzymes, enabling surface proteome analysis of cells and exosomes with high coverage and quantification of 1,020 surface proteins.

bioRxiv · Sep 22, 2021Biochemistry

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.

J. Patten, P. T. Keiser, D. M. Gysi, G. Menichetti, H. Mori, C. J. Donahue, X. Gan, I. F. do Valle, K. Geoghegan-Barek, M. Anantpadma, R. Boytz, J. L. Berrigan, S. Hulsey-Stubbs, K. T. Ayazika, C. O'Leary, , R. A. Davey

The paper identifies 389 small molecules and 813 host targets that inhibit SARS-CoV-2 infection through in vitro and in vivo testing, using computational integration of drug activity and cellular networks.

bioRxiv · Apr 20, 2021 · PreprintMicrobiology

Clonal expansion of personalized anti-tumor T cells from circulation using tumor organoid-immune co-cultures

Q. Meng, S. Xie, K. Gray, W. Li, L. Huang, D. Akshinthala, M. Dezfulian, E. Ferrer, C. Conahan, S. Del Pino, J. Grossman, S. Elledge, M. Hidalgo, S. K. Muthuswamy

This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.

bioRxiv · Nov 6, 2020 · PreprintCancer Biology

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

I. Lui, X. X. Zhou, S. A. Lim, S. Elledge, P. Solomon, N. J. Rettko, B. S. Zha, L. L. Kirkemo, J. A. Gramespacher, J. Liu, F. Muecksch, J. C. C. Lorenzi, F. Schmidt, Y. Weisblum, D. F. Robbiani, , J. A. Wells

This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.

bioRxiv · May 21, 2020 · PreprintBiochemistry