Author

S. K. Muthuswamy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. Akshinthala· 2 shared A. Geier· 1 shared A. K. Kesarwani· 1 shared A. R. Asthagiri· 1 shared A. R. Krainer· 1 shared C. Conahan· 1 shared C. Hu· 1 shared E. Ferrer· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

D. Akshinthala

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5 papers

Recent·Most cited

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer

M. U. Oliphant, D. Akshinthala, S. K. Muthuswamy

This study develops a culture medium that maintains ER+ breast cancer organoids' estrogen responsiveness and drug sensitivity, enabling better study of therapy response and disease progression.

bioRxiv · Aug 9, 2023Cancer Biology

Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids

R. Desai, S. K. Muthuswamy

This study investigates how oncogenic GNASR201C induces cell proliferation in pancreatic ductal and acinar organoids through PKA-dependent and independent mechanisms.

bioRxiv · Jan 16, 2023Cancer Biology

Clonal expansion of personalized anti-tumor T cells from circulation using tumor organoid-immune co-cultures

Q. Meng, S. Xie, K. Gray, W. Li, L. Huang, D. Akshinthala, M. Dezfulian, E. Ferrer, C. Conahan, S. Del Pino, J. Grossman, S. Elledge, M. Hidalgo, S. K. Muthuswamy

This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.

bioRxiv · Nov 6, 2020 · PreprintCancer Biology

Differential functions of splicing factors in breast-cancer initiation and metastasis

S. Das, M. Akerman, S. Park, M. Brugioli, A. Geier, A. K. Kesarwani, M. Fan, N. Leclair, L. Urbanski, K.-T. Lin, C. Hu, X. Hua, J. George, S. K. Muthuswamy, A. R. Krainer, O. Anczukow

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

bioRxiv · May 10, 2019Cancer Biology

Golgi stabilization, not its front-rear bias, is associated with EMT-enhanced fibrillar migration

R. J. Natividad, M. L. Lalli, S. K. Muthuswamy, A. R. Asthagiri

This study shows that EMT enhances migration on collagen tracks by stabilizing Golgi positioning, not by altering its front-rear bias.

bioRxiv · Apr 25, 2018Cell Biology