Author

D. Akshinthala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:organoid / primary culture· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Grossman· 2 shared L. Huang· 2 shared M. Hidalgo· 2 shared S. K. Muthuswamy· 2 shared A. Bose· 1 shared A. Emili· 1 shared B. Bockorny· 1 shared C. Conahan· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

J. Grossman

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3 papers

Recent·Most cited

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer

M. U. Oliphant, D. Akshinthala, S. K. Muthuswamy

This study develops a culture medium that maintains ER+ breast cancer organoids' estrogen responsiveness and drug sensitivity, enabling better study of therapy response and disease progression.

bioRxiv · Aug 9, 2023Cancer Biology

Clonal expansion of personalized anti-tumor T cells from circulation using tumor organoid-immune co-cultures

Q. Meng, S. Xie, K. Gray, W. Li, L. Huang, D. Akshinthala, M. Dezfulian, E. Ferrer, C. Conahan, S. Del Pino, J. Grossman, S. Elledge, M. Hidalgo, S. K. Muthuswamy

This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.

bioRxiv · Nov 6, 2020 · PreprintCancer Biology

Pancreatic tumor organoids for modeling in vivo drug response and discovering clinically-actionable biomarkers

l. huang, B. Bockorny, I. Paul, D. Akshinthala, O. Gandarilla, A. Bose, V. Sanchez-Gonzalez, E. Rouse, S. Lehoux, N. Pandell, J. Clohessy, J. Grossman, R. Gonzalez, S. Perea del Pino, G. Daaboul, , S. Muthuswamy

This paper demonstrates that pancreatic tumor organoids (PDOs) recapitulate PDX models' features and can identify clinically-actionable biomarkers in blood.

bioRxiv · Jan 28, 2019 · PreprintCancer Biology