M. Di Cristina

This study identifies and characterizes RDF1 and RDF2, two T. gondii proteins essential for rhoptry exocytosis, revealing a compensatory mechanism that contributes to phenotypic plasticity.

This study identifies TgGRA14 as a parasite protein that recruits the host ESCRT machinery to facilitate uptake of host cytosolic proteins across the parasitophorous vacuole membrane.

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.

This study shows that CPL is the dominant protease in Toxoplasma gondii's VAC, while CPB and ASP1 have dispensable roles in protein digestion.

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.