Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy
C. LI, S. Mao, H. Zhao, M. He, M. Wang, Z. Liu, H. Wen, Z. Yu, B. Wen, M. Djibo, J. Tao, Y. Bu, W. Gao, D. Sun
This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.
bioRxiv · Feb 14, 2024 · PreprintPharmacology & Toxicology