J. Tao

Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments

The paper introduces a competitive partitioning model to distinguish effects of species interactions on ecosystem productivity using simulated and experimental data.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

Post-translational regulation of Platelet-derived growth factor receptor β is critical for fracture repair in aged mice

This study identifies PDGFRβ as a target of proteasome inhibitors in aged mice, showing that its degradation impairs fracture repair and that combined PDGF-BB and proteasome inhibitor treatment improves repair.

Western diet unmasks transient low-level vinyl chloride exposure-induced tumorigenesis; potential role of the (epi-)transcriptome

This study shows that low-level vinyl chloride exposure combined with a Western diet increases liver cancer risk in mice through metabolic and epitranscriptomic changes.

Transcriptome mining of RNA viruses (family Totiviridae) in Eimeria necatrix and Eimeria stiedai

The paper identifies and analyzes two new Totiviridae viruses in Eimeria species, revealing phylogenetic insights and suggesting a new genus classification.

Metal-driven anaerobic oxidation of methane as an important methane sink in methanic cold seep sediments

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

Excess PrPC inhibits muscle cell differentiation via miRNA-enhanced liquid-liquid phase separation implicated in myopathy

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis

This study identifies Calponin 2's role in kidney fibrosis by linking cellular mechanics to metabolic reprogramming via fatty acid oxidation regulation.

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

This study investigates how mammalian spindle length is maintained by showing that kinetochore-fibers can self-regulate their length without pole-focusing forces, but poles coordinate length across fibers.

Evolution of m6A related genes in insects and function of METTL3 in embryonic development of silkworm.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

HIV positive patients on antiretroviral therapy have an altered mucosal intestinal but not oral microbiome

This study compares the intestinal and oral microbiome composition and function between HIV-positive and uninfected individuals, finding significant intestinal changes but no oral differences.

GTEM cell design for controlled exposure to electromagnetic fields in biological system

This paper designs a GTEM cell for controlled electromagnetic field exposure in biological systems, showing it meets reflection and field uniformity criteria through simulation and testing.

Serum Amyloid A promotes Acetaminophen-induced liverinjury by damaging sinusoidal endothelial cell and exacerbating platelet aggregation in liver

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

Mechanical Compression Creates a Quiescent Muscle Stem Cell Niche

This study shows that mechanical compression of muscle stem cells induces quiescence by altering tension and activating Notch signaling independently of canonical cleavage.

Directing multicellular organization by varying the aspect ratio of soft hydrogel microwells

This study shows that endothelial cells self-organize into ring-like patterns on hydrogel microwells based on geometry and substrate stiffness, independent of chemical cues.

Horizontal gene transfer of a unique nif island drives convergent evolution of free-living N2-fixing Bradyrhizobium

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

Allantoin induces pruritus by activating MrgprD in chronic kidney disease

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

Deletion and overexpression of the scaffolding protein IQGAP1 promotes HCC

This study shows that both deletion and overexpression of IQGAP1 promote hepatocellular carcinoma (HCC) through distinct mechanisms.

Rottlerin ameliorates DSS-induced colitis by improving intestinal barrier function via activation of the Epac-2/Rap-1 signaling pathway.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

YAP/TAZ as a Novel Regulator of cell volume

This study identifies YAP/TAZ as regulators of single-cell volume, showing their role extends beyond cell cycle duration and shape, and they influence division volume independently of mTOR.

Engrafted parenchymal brain macrophages differ from host microglia in transcriptome, epigenome and response to challenge

This study compares transcriptomes, epigenomes, and responses to challenge between engrafted HSC-derived brain macrophages and host microglia, finding persistent molecular and functional differences.

Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma

The paper identifies and models a gene regulatory network linking LIN28B-dependent dedifferentiation with CTNNB1 dysfunction in HCC, predicting drug response and cell state dynamics.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.

Role of Membrane-tension Gated Ca Flux in Cell Mechanosensation

The paper demonstrates that membrane tension-sensitive calcium currents and ion channels regulate Rho GTPase and myosin contraction, and that YAP translocates in response to mechanical compression.