S. Mao

SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity Through B Cell Antigen Presentation

This study develops a neoantigen vaccine using SARS-CoV-2 B cell epitopes to enhance CD4/CD8 T cell immunity through B cell antigen presentation, showing improved efficacy in multiple cancer models.

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink

This study identifies shallow-water chemosymbiotic clams as a significant, previously overlooked carbon sink in the Yellow Sea, contributing 43% of the region's sedimental carbon burial.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins

The paper identifies a small-molecule stimulator of the human Hsp70-disaggregase system that selectively activates DnaJB1- or DnaJB4-containing chaperone complexes.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

CAR T-cell therapy- Paving the way for sensitized kidney transplant patients.

This paper explores using CAR T-cells targeting BAFF-R to treat sensitized kidney transplant patients, showing cytotoxicity against autologous B cells and paving the way for clinical trials.

MAPS: Pathologist-level cell type annotation from tissue images through machine learning

MAPS provides pathologist-level cell type annotation from spatial proteomics data using machine learning, outperforming existing methods in speed and accuracy.

Ripening, bursting, and synchronization of biomolecular condensates in a heterogeneous elastic medium

This paper introduces a novel simulation method to model biomolecular condensate dynamics in chromatin, revealing unique scaling behaviors and synchronization phenomena.

The Prophylactic and Therapeutic Efficacy of the Broadly Active Antiviral Ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a Mouse Model of Lethal Ebola Virus Infection

This study evaluates the efficacy of EIDD-1931, a ribonucleoside analog, in preventing and treating lethal Ebola virus infection in mice.

Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung Carcinoma

The paper uses spatial transcriptomics to analyze lung cancer heterogeneity, identifying gene expression gradients and tumor subclones, and infers metastasis trajectories through pseudo-time modeling.

Base Pairing and Functional Insights into N3-methylcytidine (m3C) in RNA

This study investigates the effects of N3-methylcytidine (m3C) modification on RNA base pairing and reverse transcription, showing its impact on stability, discrimination, and mutation induction.

Tracing two causative SNPs reveals SARS-CoV-2 transmission in North America population

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

This study shows valproic acid corrects the folding and trafficking defect of the I1061T-NPC1 mutation, restoring cholesterol homeostasis and suggesting a potential therapeutic approach for Niemann-Pick type C disease.

CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs

The paper shows CELF1 binds eIF4E and PABP to promote translation of EMT effector mRNAs, and disrupting this interaction inhibits EMT and metastasis.

Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia

The paper investigates ESC-R-EC and ESC-R-KP colonization in Cambodian children, identifies risk factors, and characterizes resistance gene diversity and genetic contexts.