The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes
M. Lu, F. W. van Tartwijk, J. Q. Lin, W. Nijenhuis, P. Parutto, M. Fantham, C. N. Christensen, E. Avezov, C. E. Holt, A. Tunnacliffe, D. Holcman, L. Kapitein, G. Kaminski Schierle, C. F. Kaminski
This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.
bioRxiv · Jan 15, 2020Cell Biology