W. Nijenhuis

Aurora B controls microtubule stability to regulate abscission dynamics in stem cells

The paper shows Aurora B regulates abscission speed in stem cells by controlling microtubule stability through a feedback loop.

The SARS-CoV-2 accessory factor ORF7a downregulates MHC class I surface expression

This study identifies SARS-CoV-2 ORF7a as a viral factor that downregulates MHC class I surface expression, impairing antigen presentation and immune surveillance.

A motor-based approach to induce chromosome-specific mis-segregations in human cells

This paper introduces a motor-based method to induce chromosome-specific mis-segregations in human cells, revealing how spindle forces can cause aneuploidies.

Opto-Katanin: An Optogenetic Tool for Localized Microtubule Disassembly

This paper introduces opto-katanin, a light-activated tool for localized microtubule disassembly, enabling precise spatiotemporal control in mammalian cells.

Self-assembly of pericentriolar material in interphase cells lacking centrioles

This study shows that PCM can self-assemble into a compact MTOC in interphase cells without centrioles, using dynein transport and self-clustering, but this process is sensitive to motor and microtubule dynamics.

Optical nanoscopy reveals SARS-CoV-2-induced remodeling of human airway cells

This study uses advanced microscopy to show how SARS-CoV-2 changes the structure of human airway cells at the subcellular level.

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

This study develops an improved method to measure CFTR drug responses in nasal airway organoids derived from 2D differentiated epithelial cells.

Direct observation of aggregate-triggered selective autophagy

This study develops and applies a live-cell assay to observe and quantify the dynamics of aggrephagy, revealing key spatiotemporal features of autophagosome formation and cargo-driven initiation.

Co-translational targeting of transcripts to endosomes

The paper identifies mRNAs that associate with early endosomes and shows that the coding region of EEA1 mRNA is sufficient for endosomal localization.

The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes

This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.