L. Kapitein

A motor-based approach to induce chromosome-specific mis-segregations in human cells

This paper introduces a motor-based method to induce chromosome-specific mis-segregations in human cells, revealing how spindle forces can cause aneuploidies.

Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells.

The paper investigates cortical complexes in β-cells that regulate insulin secretion, identifying non-neuronal proteins and showing their role in organizing secretory machinery at integrin-based adhesions.

3D multi-color far-red single-molecule localization microscopy with probability-based fluorophore classification

This paper introduces a method for multi-color single-molecule localization microscopy using probability-based fluorophore classification, improving accuracy and reducing false positives.

Matrix elasticity gradients guide neuronal polarity by controlling microtubule network mobility

This study shows that extracellular elasticity gradients guide neuronal polarity by controlling microtubule network mobility and Rho-GTPase activation, leading to polarized transport and axon specification.

Direct observation of aggregate-triggered selective autophagy

This study develops and applies a live-cell assay to observe and quantify the dynamics of aggrephagy, revealing key spatiotemporal features of autophagosome formation and cargo-driven initiation.

Quantitative mapping of dense microtubule arrays in mammalian neurons

The paper maps the three-dimensional organization and abundance of microtubule subtypes in mammalian neurons using super-resolution imaging and a novel analysis pipeline.

The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes

This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.