STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity
B. Patel, Y. Zhou, R. L. Babcock, F. Ma, M. A. Zal, D. Kumar, Y. B. Medik, L. M. Kahn, J. E. Pineda, E. M. Park, X. Tang, M. G. Raso, T. Zal, K. Clise-Dwyer, F. G. Giancotti, , S. S. Watowich
This study shows that STAT3 is essential for maintaining hematopoietic stem cell function by suppressing interferon signaling and myeloid skewing, and its loss leads to impaired hematopoietic activity.
bioRxiv · Feb 10, 2023 · PreprintImmunology