M. Gautel

Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C

The paper develops a machine learning model to predict the impact of missense variants in human filamin C, achieving high accuracy in distinguishing pathogenic from non-pathogenic variants.

In situ structures from relaxed cardiac myofibrils reveal the organization of the muscle thick filament

This study reveals the 3D structure of relaxed cardiac sarcomeres using cryo-electron tomography, showing how thick filament components interact and function in muscle contraction.

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro

The paper investigates obscurin GEF domains, showing they are phosphorylated by MST-family kinases but lack detectable nucleotide exchange activity towards Rho GTPases in vitro.

Structure of the thin filament in native skeletal muscles reveals its interaction with nebulin and two distinct conformations of myosin

The paper presents the first structure of native nebulin bound to thin filaments in sarcomeres, revealing interactions with actin and myosin conformations, and the molecular basis of nebulin's role in muscle function.

Sub-diffraction error mapping for localization microscopy images

The paper introduces HAWKMAN, a method to map and quantify artificial sharpening errors in localization microscopy images using Haar wavelet kernel analysis.

Molecular plasticity of the native mouse skeletal sarcomere revealed by cryo-ET

This study uses cryo-ET to reveal the molecular architecture of mouse skeletal sarcomeres, showing detailed interactions and conformational plasticity in actin and myosin filaments.