Insulin B peptide-MHC class II-specific chimeric antigen 1 receptor-Tregs prevent autoimmune diabetes
J. A. Spanier, V. Fung, C. M. Wardell, M. H. Alkhatib, Y. Chen, L. A. Swanson, A. J. Dwyer, M. E. Weno, N. Silva, J. S. Mitchell, P. C. Orban, M. Mojibian, C. B. Verchere, B. T. Fife, M. K. Levings
This paper demonstrates that InsB-g7 CAR Tregs specific for an insulin B-chain peptide prevent autoimmune diabetes in NOD mice.
bioRxiv · Feb 23, 2023 · PreprintImmunology