Author

C. B. Verchere

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Immunology· 2 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell type annotation· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

Y.-C. Chen· 3 shared A. E. Patterson· 2 shared G. Soukhatcheva· 2 shared A. C. Swensen· 1 shared A. J. Dwyer· 1 shared A. J. Taylor· 1 shared A. M. Klimek-Abercrombie· 1 shared A. Z. L. Shih· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersPhysiology

Y.-C. Chen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

J. H. Oh, R. A. Cederberg, L. Bopp, E. Tanaka, T. Ser, S. Niyyati, A. E. Patterson, N. Amanat, J. Dutra, P. Ye, M. Clark, K. Ward-Hartstonge, A.-S. Archambault, J. Tsui, P. F. Lange, , R. I. K. Geltink

This study shows that inducing an oxidized redox balance in CD8+ T cells enhances their anti-tumor function in vivo through increased mitochondrial ROS.

bioRxiv · Mar 27, 2023 · PreprintImmunology

Insulin B peptide-MHC class II-specific chimeric antigen 1 receptor-Tregs prevent autoimmune diabetes

J. A. Spanier, V. Fung, C. M. Wardell, M. H. Alkhatib, Y. Chen, L. A. Swanson, A. J. Dwyer, M. E. Weno, N. Silva, J. S. Mitchell, P. C. Orban, M. Mojibian, C. B. Verchere, B. T. Fife, M. K. Levings

This paper demonstrates that InsB-g7 CAR Tregs specific for an insulin B-chain peptide prevent autoimmune diabetes in NOD mice.

bioRxiv · Feb 23, 2023 · PreprintImmunology

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

Y.-C. Chen, A. J. Taylor, J. M. Fulcher, A. C. Swensen, X.-Q. Dai, M. Komba, K. L. C. Wrightson, K. Fok, A. E. Patterson, R. I. Klein-Geltink, P. E. MacDonald, W.-J. Qian, C. B. Verchere

This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.

bioRxiv · Oct 20, 2022 · PreprintPhysiology

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

A. Z. L. Shih, Y.-C. Chen, C. B. Verchere, T. Willnow

This study shows SORLA reduces islet amyloid deposition by mediating endocytic uptake of proIAPP, preventing cell death in pancreatic beta cells.

bioRxiv · Apr 21, 2022Cell Biology

Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients

Y.-C. Chen, A. M. Klimek-Abercrombie, K. J. Potter, L. P. Pallo, G. Soukhatcheva, D. Lei, M. Bellin, C. B. Verchere

The paper identifies elevated prohormone ratios as indicators of insulin dependency in islet transplant recipients using human and mouse models.

bioRxiv · Oct 17, 2021 · PreprintPathology

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

E. Panzhinskiy, S. Skovso, H. H. Cen, K. Y. Chu, K. MacDonald, G. Soukhatcheva, D. A. Dionne, L. K. Hallmaier-Wacker, J. S. Wildi, S. Marcil, N. Noursadeghi, F. Taghizadeh, C. B. Verchere, E. Jan, J. D. Johnson

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

bioRxiv · Feb 17, 2021 · PreprintPhysiology

T cells are present in non-diabetic islets and accumulate during aging.

H. C. Denroche, S. Miard, S. Salle-Lefort, F. Picard, C. B. Verchere

The paper shows T cells are present in non-diabetic islets and increase with age in mice and humans, independent of body weight.

bioRxiv · Jul 21, 2020Physiology