V. Fung

CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation

A2-CAR Tregs reduce BDC2.5 T cell engraftment, proliferation, and cytokine production, protecting mice from diabetes and inducing systemic tolerance.

Insulin B peptide-MHC class II-specific chimeric antigen 1 receptor-Tregs prevent autoimmune diabetes

This paper demonstrates that InsB-g7 CAR Tregs specific for an insulin B-chain peptide prevent autoimmune diabetes in NOD mice.

Engineering Escherichia coli to produce aromatic chemicals from ethylene glycol

This study engineers Escherichia coli to produce aromatic chemicals from ethylene glycol, achieving higher yields than glucose and demonstrating feasibility with waste PET-derived EG.

Integration of exogenous and endogenous co-stimulatory signals by CAR-Tregs

This study compares CAR-Treg function with different co-stimulatory domains, finding in vivo equivalence between CARs with and without CD28 despite in vitro differences.

Improving glycine utilization in Escherichia coli

This study engineers Escherichia coli to utilize glycine as a carbon and nitrogen source, identifying a stable pathway and genetic modifications that enhance its metabolic efficiency.

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs

This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.

Endogenous BioID elucidates TCF7L1 interactome modulation upon GSK-3 inhibition in mouse ESCs

The paper uses BioID to study TCF7L1 interactome changes in mouse ESCs with GSK-3 inhibition, identifying new interactors and showing increased detection with reduced BirA*-TCF7L1 levels.