SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2
Y. Lei, J. Zhang, C. R. Schiavon, M. He, L. Chen, H. Shen, Y. Zhang, Q. Yin, Y. Cho, L. Andrade, G. S. Shadel, M. Hepokoski, T. Lei, H. Wang, J. Zhang, , J. Y.-J. Shyy
This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.
bioRxiv · Dec 4, 2020Pathology