Q. Yin

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

Crystal structures reveal nucleotide-induced conformational changes in G motifs and distal regions in guanylate-binding protein 2

This study reveals how GDP binding induces conformational changes in GBP2's G domain and distal regions, leading to dimer-monomer transitions and functional regulation.

A Quadrivalent mRNA immunization elicits potent immune responses against vaccinia and monkeypox viral antigens - a step closer to a broad orthopoxvirus vaccine

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

Oligomer-to-Monomer Transition Underlies the Chaperone Function of AAGAB in AP1/AP2 Assembly

This study identifies the dual role of AAGAB's tetramerization domain in stabilizing AAGAB and binding substrates during AP1/AP2 complex assembly.

N-glucosyltransferase GbNGT1 from Ginkgo complement auxin metabolic pathway

The paper identifies GbNGT1, an N-glucosyltransferase that catalyzes IAA and IAA-amino acid glucosylation, completing the auxin metabolic pathway.

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Endosomal Sensing by Dendritic Cells in Psoriasis

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.