Generalized displacement of DNA- and RNA-binding factors mediates the toxicity of arginine-rich cell-penetrating peptides
Vanesa Lafarga, Oleksandra Sirozh, Irene Díaz‐López, M. Hisaoka, Eduardo Zarzuela, Jasminka Boskovic, Bogdan Jovanovic, Rafael Fernández-Leiro, Javier Muñoz, Georg Stoecklin, Iván Ventoso, Óscar Fernández-Capetillo
This study shows arginine-rich CPPs like (PR)n displace DNA- and RNA-binding factors, impairing nucleic acid processes and causing toxicity, similar to PROTAMINE's effects.
bioRxiv · Oct 14, 2018 · PreprintCell Biology