M. Graham

Central in vivo mechanisms by which C. difficile's proline reductase drives efficient metabolism, growth, and toxin production

This study shows that proline reductase in C. difficile is essential for metabolism, growth, and toxin production in vivo, as its absence delays colonization and disease progression in mice.

Biophysical basis of phage liquid crystalline droplet-mediated antibiotic tolerance in pathogenic bacteria

This study investigates liquid crystalline droplets formed by inoviral phages in bacteria, showing they protect cells from antibiotics through biophysical properties rather than surface chemistry.

Clostridium scindens colonization of gnotobiotic mice promotes a chronic unresolving infection with Clostridioides difficile

This study shows that C. scindens colonization in gnotobiotic mice reduces acute C. difficile infection severity but does not prevent chronic infection development.

Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background

This paper demonstrates that the Wolbachia wAlbB2-F4 strain in Ae. aegypti mosquitoes effectively inhibits dengue and Zika virus infection while retaining the genetic background of Australian mosquitoes.

Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine

This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.

Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

Optimized pseudotyping conditions for the SARS-COV2 Spike glycoprotein

This paper optimizes conditions for generating SARS-CoV-2 Spike pseudotyped viral particles, achieving high titers and demonstrating their utility in detecting neutralizing antibodies in COVID-19 patient plasma.

AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation

The paper shows AMPK and ESCRTs drive microautophagy of proteasomes during glucose starvation, leading to proteasome storage granule assembly and functional proteasome retention.

An integrated workflow for cross-linking/mass spectrometry

The paper introduces a workflow combining sequential digestion and Xi software to improve cross-linking mass spectrometry detection of protein interactions.

Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro

This study compares the roles of fibroblasts and pericytes in supporting endothelial cell self-assembly into perfusable microvascular networks in vitro.