MicrobiologybioRxiv
GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection
T. Sumitomo, M. Nakata, S. Nagase…·S. Kawabata
This study shows that GP96 promotes pneumococcal adherence to IAV-infected epithelial cells, leading to bacterial pneumonia, and that inhibiting GP96 reduces lung infection and pathology.