M. Yamaguchi

An efficient inducible model for the control of gene expression in renin cells

This paper develops an inducible mouse model to specifically control gene expression in renin cells, demonstrating efficient and targeted deletion of renin in adult mice without developmental effects.

Kaempferol exerts anti-inflammatory effects by accelerating Treg development via AhR-mediated and PU.1/IRF4-dependent transactivation of the Aldh1a2/RALDH2 gene in dendritic cells

This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.

The similarities in microbial and chemical patterns of fermentation in two open environments were promoted by using 150-year-old Nukadoko as starters.

The study tracks microbial and chemical changes in two open environments using 150-year-old nukadoko as a starter, showing similar fermentation patterns driven by Loigolactobacillus.

Gut microbiota-mediated alleviation of dextran sulfate sodium-induced colitis in mice.

The study identifies a disease-resistant BALB/c mouse substrain with a gut microbiota profile associated with reduced susceptibility to DSS-induced colitis.

Human USP18 protects diverse cancer lineages from Type I Interferon independently of its canonical catalytic function

This paper shows USP18's scaffold function, not its catalytic activity, is critical for inhibiting cancer growth and Type I interferon signaling in human cells.

Assessing the performance of the Cell Painting assay across different imaging systems

The paper evaluates Cell Painting assay performance across different imaging systems, finding compatibility and identifying optimal settings for each.

The CWI pathway is activated through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae

This study shows high hydrostatic pressure activates the CWI pathway in yeast, leading to increased glycerol efflux via Fps1 to counteract osmotic stress.

Sphingobium sp. SYK-6 syringate O-demethylase gene is regulated by DesX, unlike other vanillate and syringate catabolic genes regulated by DesR

This study identifies DesX as a regulator of desA transcription in Sphingobium sp. SYK-6, unlike DesR which regulates ligM and desB, revealing distinct regulatory mechanisms for syringate and vanillate catabolism.

GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

This study shows that GP96 promotes pneumococcal adherence to IAV-infected epithelial cells, leading to bacterial pneumonia, and that inhibiting GP96 reduces lung infection and pathology.

Three-dimensional understanding of the morphological complexity of the human uterine endometrium

This study uses 3D imaging to reveal the complex morphology of human endometrial glands and their pathological features in adenomyosis.

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.

Transcriptomic profiling of Streptococcus pyogenes M1T1 strain in a mouse model of necrotizing fasciitis

This study identifies S. pyogenes gene-expression changes in a mouse necrotizing fasciitis model, revealing upregulation of virulence factors and downregulation of oxidative-stress response genes.

Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA

This paper investigates the role of PfbA in Streptococcus pneumoniae pathogenesis, finding that it inhibits phagocytosis and modulates host inflammation, with differential effects in pneumonia and sepsis models.

Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae

The paper identifies a conserved virulence factor in Streptococcus pneumoniae through evolutionary analysis and shows its role in immune evasion.