Author

T. Sumitomo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Yamaguchi· 6 shared S. Kawabata· 6 shared M. Nakata· 5 shared Y. Hirose· 5 shared C. Nakagawa· 2 shared D. Motooka· 2 shared H. Otsuka· 2 shared M. Ono· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersMicrobiology

M. Yamaguchi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identifying Genetic Variations in emm89 Streptococcus pyogenes Linked to Severe Invasive Infections

M. Ono, M. Yamaguchi, D. Motooka, Y. Hirose, K. Higashi, T. Sumitomo, T. Miyoshi-Akiyama, R. Okuno, T. Yamaguchi, R. Kawahara, H. Otsuka, N. Nakanishi, Y. Kazawa, C. Nakagawa, R. Yamaguchi, , S. Kawabata

The paper identifies genetic variations in emm89 Streptococcus pyogenes associated with invasive infections using genome-wide association studies and validates one mutation's effect on bacterial growth.

bioRxiv · Jul 2, 2024 · PreprintMicrobiology

GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

T. Sumitomo, M. Nakata, S. Nagase, Y. Takahara, M. Honda-Ogawa, Y. Mori, M. Yamaguchi, S. Okamoto, S. Kawabata

This study shows that GP96 promotes pneumococcal adherence to IAV-infected epithelial cells, leading to bacterial pneumonia, and that inhibiting GP96 reduces lung infection and pathology.

bioRxiv · Sep 14, 2020Microbiology

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

Y. Hirose, M. Yamaguchi, N. Takemoto, T. Miyoshi-Akiyama, T. Sumitomo, M. Nakata, T. Ikebe, T. Hanada, T. Yamaguchi, R. Kawahara, R. Okuno, H. Otsuka, Y. Matsumoto, Y. Terashima, Y. Kazawa, , S. Kawabata

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.

bioRxiv · Apr 14, 2020Microbiology

Transcriptomic profiling of Streptococcus pyogenes M1T1 strain in a mouse model of necrotizing fasciitis

Y. Hirose, M. Yamaguchi, D. Okuzaki, D. Motooka, H. Hamamoto, T. Hanada, T. Sumitomo, M. Nakata, S. Kawabata

This study identifies S. pyogenes gene-expression changes in a mouse necrotizing fasciitis model, revealing upregulation of virulence factors and downregulation of oxidative-stress response genes.

bioRxiv · Apr 15, 2019 · PreprintMicrobiology

Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA

M. Yamaguchi, Y. Hirose, M. Takemura, M. Ono, T. Sumitomo, M. Nakata, Y. Terao, S. Kawabata

This paper investigates the role of PfbA in Streptococcus pneumoniae pathogenesis, finding that it inhibits phagocytosis and modulates host inflammation, with differential effects in pneumonia and sepsis models.

bioRxiv · Apr 5, 2019Microbiology

Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae

M. Yamaguchi, K. Goto, Y. Hirose, Y. Yamaguchi, T. Sumitomo, M. Nakata, K. Nakano, S. Kawabata

The paper identifies a conserved virulence factor in Streptococcus pneumoniae through evolutionary analysis and shows its role in immune evasion.

bioRxiv · Dec 11, 2018Microbiology