Author

S. Kawabata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Pathology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:mouse· 4 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:proteomics· 2 Organism:rat· 2

Frequent Co-Authors

M. Yamaguchi· 6 shared Y. Hirose· 6 shared M. Nakata· 5 shared T. Sumitomo· 5 shared T. Hanada· 3 shared S. Okamoto· 2 shared A. Ashida· 1 shared A. Tenma· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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6 shared papersMicrobiology

M. Yamaguchi

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Gut microbiota-mediated alleviation of dextran sulfate sodium-induced colitis in mice.

E. Ikeda, M. Yamaguchi, S. Kawabata

The study identifies a disease-resistant BALB/c mouse substrain with a gut microbiota profile associated with reduced susceptibility to DSS-induced colitis.

bioRxiv · Aug 7, 2023Microbiology

Biochemical reactions between intra-articular tissues and joint instability in a rat model of osteoarthritis

K. Murata, S. Kawabata, T. Kojima, Y. Oka, C. Takasu, H. Terada, N. Kanemura

This study investigates the role of joint instability in osteoarthritis progression using a rat model, finding that joint instability exacerbates cartilage degeneration and that TGF-β1 inhibition may reduce synovial inflammation.

bioRxiv · Mar 28, 2023 · PreprintPathology

Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins

Y. Hirose, S. Poudel, A. V. Sastry, R. Szubin, D. C. Zielinski, H. G. Lim, N. D. Menon, H. Bergsten, S. Uchiyama, T. Hanada, S. Kawabata, B. O. Palsson, V. Nizet

The paper identifies carbon sources that regulate hemolytic toxin expression in Streptococcus pyogenes using transcriptome-wide independent component analysis.

bioRxiv · Aug 4, 2022Microbiology

A selective glucocorticoid receptor modulator attenuates lung inflammation and improves alveolarization in a neonatal rat model of bronchopulmonary dysplasia.

S. Ishikawa, T. Ogihara, S. Yamaoka, J. Shinohara, S. Kawabata, Y. Hirose, A. Ashida

This study shows that Compound A reduces lung inflammation and improves alveolarization in a neonatal rat model of bronchopulmonary dysplasia.

bioRxiv · Apr 28, 2021 · PreprintPathology

Preclinical study of DNA vaccines targeting SARS-CoV-2

H. Hayashi, J. Sun, Y. Yanagida, T. Otera, R. Kubota-Kotetsu, T. Shioda, C. Ono, Y. Matsuura, H. Arase, S. Yoshida, R. Nakamaru, R. Ide, A. Tenma, S. Kawabata, T. Ehara, , H. Nakagami

This study evaluates a DNA vaccine targeting SARS-CoV-2 Spike protein, showing enhanced humoral and cellular immune responses and neutralizing antibody activity.

bioRxiv · Oct 21, 2020Immunology

GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

T. Sumitomo, M. Nakata, S. Nagase, Y. Takahara, M. Honda-Ogawa, Y. Mori, M. Yamaguchi, S. Okamoto, S. Kawabata

This study shows that GP96 promotes pneumococcal adherence to IAV-infected epithelial cells, leading to bacterial pneumonia, and that inhibiting GP96 reduces lung infection and pathology.

bioRxiv · Sep 14, 2020Microbiology

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

Y. Hirose, M. Yamaguchi, N. Takemoto, T. Miyoshi-Akiyama, T. Sumitomo, M. Nakata, T. Ikebe, T. Hanada, T. Yamaguchi, R. Kawahara, R. Okuno, H. Otsuka, Y. Matsumoto, Y. Terashima, Y. Kazawa, , S. Kawabata

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.

bioRxiv · Apr 14, 2020Microbiology

Transcriptomic profiling of Streptococcus pyogenes M1T1 strain in a mouse model of necrotizing fasciitis

Y. Hirose, M. Yamaguchi, D. Okuzaki, D. Motooka, H. Hamamoto, T. Hanada, T. Sumitomo, M. Nakata, S. Kawabata

This study identifies S. pyogenes gene-expression changes in a mouse necrotizing fasciitis model, revealing upregulation of virulence factors and downregulation of oxidative-stress response genes.

bioRxiv · Apr 15, 2019 · PreprintMicrobiology

Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA

M. Yamaguchi, Y. Hirose, M. Takemura, M. Ono, T. Sumitomo, M. Nakata, Y. Terao, S. Kawabata

This paper investigates the role of PfbA in Streptococcus pneumoniae pathogenesis, finding that it inhibits phagocytosis and modulates host inflammation, with differential effects in pneumonia and sepsis models.

bioRxiv · Apr 5, 2019Microbiology

Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae

M. Yamaguchi, K. Goto, Y. Hirose, Y. Yamaguchi, T. Sumitomo, M. Nakata, K. Nakano, S. Kawabata

The paper identifies a conserved virulence factor in Streptococcus pneumoniae through evolutionary analysis and shows its role in immune evasion.

bioRxiv · Dec 11, 2018Microbiology