Author

M. Horlbeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Ashok· 1 shared A. Heslin· 1 shared A. Sweet-Cordero· 1 shared A. Tulpule· 1 shared A.-F. Galic· 1 shared C. M. Butnaru· 1 shared D. Gracilla· 1 shared E. De Stanchina· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

A. Ashok

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Author profile →

2 papers

Recent·Most cited

FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy

S. Menon, D. Gracilla, M. R. Breese, Y. P. Lin, F. S. Dela Cruz, T. Feinberg, E. De Stanchina, A.-F. Galic, H. Allegakoen, s. perati, N. Wen, A. Heslin, M. Horlbeck, J. S. Weissman, A. Sweet-Cordero, , A. Tulpule

This study shows FET fusion oncoproteins disrupt DNA repair by inhibiting ATM signaling, making ATR inhibitors a potential therapy for FET rearranged cancers.

bioRxiv · Apr 30, 2023 · PreprintCancer Biology

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells

L. Bassaganyas, S. J. Popa, M. Horlbeck, A. Ashok, S. E. Stewart, C. M. Butnaru, N. Brouwers, K. Heydari, J. Ripoche, J. Weissman, R. Schekman, V. Malhotra, K. Moreau, J. Villeneuve

The paper identifies two new factors, TTC17 and CCDC157, involved in protein transport through a CRISPRi screen in mammalian cells, showing their roles in Golgi structure and transport carrier fusion.

bioRxiv · Feb 21, 2019Cell Biology