N. Brouwers

Defects in lipid homeostasis reflect the function of TANGO2 in Acyl-CoA metabolism

The paper shows that TANGO2 deficiency disrupts lipid homeostasis by altering acyl-CoA metabolism, leading to increased lipid droplets and reactive oxygen species.

Biphasic release propensity of mucin granules is supervised by TSPAN8

The paper identifies TSPAN8 as a regulator of biphasic mucin release by sequestering syntaxin-2, preventing reserve granule docking and increasing secretion in its absence.

The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins

This study shows that FUT8 regulates mucin secretion and viscoelastic properties, linking its dysfunction to ulcerative colitis pathogenesis.

Building new compartments for unconventional protein secretion from the early and late Golgi membranes

The paper identifies CUPS and TCUPS as compartments involved in unconventional protein secretion, showing their dynamics and relationship to the Golgi during starvation.

Palmitoylation of KChIP3 controls baseline mucin secretion

This study shows that palmitoylation of KChIP3 by zDHHC3 or zDHHC4 is required for its recruitment to mucin granules, thereby regulating baseline mucin secretion.

Reactive oxygen species (ROS) triggers unconventional secretion of antioxidants and Acb1

The paper shows that starvation induces ROS production, which triggers the unconventional secretion of antioxidants and Acb1, aiding cell regrowth upon nutrient repletion.

Maltotriose consumption by hybrid Saccharomyces pastorianus is heterotic and results from regulatory cross-talk between parental sub-genomes

This study shows that maltotriose consumption in S. pastorianus hybrids arises from regulatory cross-talk between parental sub-genomes, demonstrating heterosis in this industrially relevant trait.

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells

The paper identifies two new factors, TTC17 and CCDC157, involved in protein transport through a CRISPRi screen in mammalian cells, showing their roles in Golgi structure and transport carrier fusion.

Laboratory evolution of a Saccharomyces cerevisiae x S. eubayanus hybrid under simulated lager-brewing conditions: genetic diversity and phenotypic convergence

This study evolves a Saccharomyces cerevisiae x S. eubayanus hybrid under brewing conditions, showing phenotypic diversity and limited aneuploidy, with specific mutations linked to industrial traits.

In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation

This study enables maltotriose fermentation in Saccharomyces eubayanus by evolving a chimeric transporter gene through recombination of existing maltose-transporter genes.