Author

M. I. Vitolo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

R. M. Lee· 3 shared S. S. Martin· 3 shared W. Losert· 2 shared A. A. Gad· 1 shared C. Ling· 1 shared D. A. Annis· 1 shared D. E. Gilchrist· 1 shared J. A. Ju· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

R. M. Lee

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions

M. L. Mull, S. J. P. Pratt, K. N. Thompson, D. A. Annis, A. A. Gad, R. M. Lee, K. T. Chang, M. B. Stemberger, J. A. Ju, D. E. Gilchrist, L. Boyman, M. I. Vitolo, W. J. Lederer, S. S. Martin

This study shows that P2Y2 receptor signaling, which increases intracellular calcium and actin localization in non-tumorigenic breast cells, is disrupted in metastatic cells, promoting dissemination.

bioRxiv · Mar 31, 2023Cancer Biology

Label-free Cell Tracking Enables Collective Motion Phenotyping in Epithelial Monolayers

S. Gu, R. M. Lee, Z. Benson, C. Ling, M. I. Vitolo, S. S. Martin, J. Chalfoun, W. Losert

The paper introduces an AI-based pipeline to track cell nuclei in phase contrast images and uses it to analyze collective motion in epithelial monolayers, finding that D2min correlates with metastatic potential.

bioRxiv · Dec 14, 2021Biophysics

Distinct Roles of Tumor-Associated Mutations in Collective Cell Migration

R. M. Lee, M. I. Vitolo, W. Losert, S. S. Martin

The paper investigates how tumor-associated mutations affect collective cell migration, finding that PTEN deletion enhances it while Ras activation suppresses it, with implications for metastasis.

Scientific Reports · May 13, 2021Peer-reviewedBiophysics