Author

W. J. Lederer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

L. Boyman· 4 shared A. K. Coleman· 3 shared M. Greiser· 3 shared A. D. Kaplan· 2 shared C. W. Ward· 2 shared M. Karbowski· 2 shared A. A. Gad· 1 shared C. A. Mannella· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPhysiology

L. Boyman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Na+/K+ATPase - Cav1.2 nanodomain differentially regulates intracellular and local adrenergic signaling in cardiac myocytes

M. Karbowski, L. Boyman, L. Garber, H. Joca, N. Verhoeven, A. K. Coleman, C. Ward, W. J. Lederer, M. Greiser

The paper investigates how the NKA1-Cav1.2 nanodomain differentially regulates intracellular Na+ and Ca2+ homeostasis in atrial and ventricular myocytes through local adrenergic signaling.

bioRxiv · Aug 31, 2023 · PreprintPhysiology

Ryanodine Receptor Stabilization Therapy Suppresses Ca2+- Based Arrhythmias in a Novel Model of Metabolic HFpEF

A. D. Kaplan, L. Boyman, C. W. Ward, W. J. Lederer, M. Greiser

This study develops a novel HFpEF model and shows that ryanodine receptor stabilization with dantrolene prevents stress-induced ventricular tachycardia in metabolic HFpEF.

bioRxiv · Jun 21, 2023Physiology

Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions

M. L. Mull, S. J. P. Pratt, K. N. Thompson, D. A. Annis, A. A. Gad, R. M. Lee, K. T. Chang, M. B. Stemberger, J. A. Ju, D. E. Gilchrist, L. Boyman, M. I. Vitolo, W. J. Lederer, S. S. Martin

This study shows that P2Y2 receptor signaling, which increases intracellular calcium and actin localization in non-tumorigenic breast cells, is disrupted in metastatic cells, promoting dissemination.

bioRxiv · Mar 31, 2023Cancer Biology

Calcium and Bicarbonate Signaling Pathways have Pivotal, Resonating Roles in Matching ATP Production to Demand

M. Greiser, M. Karbowski, A. D. Kaplan, A. K. Coleman, C. A. Mannella, W. J. Lederer, L. Boyman

This study identifies bicarbonate signaling via sAC as a third regulatory system that complements Ca2+ signaling to control mitochondrial ATP production in cardiac myocytes.

bioRxiv · Oct 31, 2022Physiology

Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle

A. K. Coleman, H. C. Joca, G. Shi, W. J. Lederer, C. W. Ward

The paper investigates how acetylated α-tubulin affects cytoskeletal stiffness and mechanotransduction in striated muscle by increasing its levels without changing detyrosinated α-tubulin.

bioRxiv · Jun 10, 2020Physiology